3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole

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产品名称：3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole

产品别名：3-[[3-fluoro-5-(4-methoxyoxan-4-yl)phenoxy]methyl]-1-(4-methylsulfonylphenyl)-5-phenylpyrazole

CAS号：443919-96-8

英文别名：3-[[3-fluoro-5-(4-methoxyoxan-4-yl)phenoxy]methyl]-1-(4-methylsulfonylphenyl)-5-phenylpyrazole

分子量：536.6

分子式：C₂₉H₂₉FN₂O₅S

纯度：>95%

外观：见爱必信官网

保存方法：Store at -20° C

描述：3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole is a dual inhibitor of Cox-2 (cyclooxygenase-2) and 5-LO (5-lipoxygenase) (IC₅₀ of 50 nM and 3 nM, respectively). 3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole is selective for Cox-2 over Cox-1 by greater than 200-fold. Cox-2/5-LO inhibitors are also apoptosis-inducing agents and are potentially useful in prostate cancer chemotherapy. In the PC3 human carcinoma cell line, 3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole exhibits a 45% inhibition of proliferation at 100 μM, and in the LNCaP human carcinoma cell line, a IC₅₀ value of 83 μM.

应用：A dual inhibitor of Cox-2 and 5-LO

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