3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide,dibenzyl (2S)-2-[3-(3,4-dihydroxyphenyl)propanoylamino]butanedioate,615264-62-5

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产品名称：3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide

产品别名：N-​[3-​(3,​4-​dihydroxyphenyl)-​1-​oxopropyl]-​L-​aspartic acid,​ bis(phenylmethyl) ester

CAS号：615264-62-5

英文别名：N-​[3-​(3,​4-​dihydroxyphenyl)-​1-​oxopropyl]-​L-​aspartic acid,​ bis(phenylmethyl) ester

分子量：477.5

分子式：C₂₇H₂₇NO₇

纯度：见爱必信官网

外观：Crystalline

保存方法：Store at -20° C

描述：3,4-dihydroxy Hydrocinnamic acid (L-Aspartic acid dibenzyl ester) amide inhibits human ACAT-1 and ACAT-2 (Acyl-Coenzyme A cyltransferase-1 and -2) equally with an IC₅₀ of about 60 μM. ACAT-1 and ACAT-2 catalyze the formation of long chain fatty acyl-coenzyme A and cholesterol esters from cholesterol, and may play a role in the development of atherosclerosis. This chemical inhibits human ACAT-1 and ACAT-2 with an IC50 values of 95 and 81 μM, respectively and also inhibits copper-mediated oxidation of low density lipoproteins by 91% at a concentration of 2 μM.

应用：A cholesterol acyltransferase-1 and -2 inhibitor

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