Sulindac Sulfide,硫化舒林酸,32004-67-4

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试剂描述：

产品名称：Sulindac Sulfide

产品别名：Z-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid

CAS号：32004-67-4

英文别名：Z-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid

分子量：340.41

分子式：C₂₀H₁₇FO₂S

纯度：≥99%

外观：见爱必信官网

保存方法：Store at room temperature

描述：Sulindac Sulfide, a metabolite of Sulindac , is a non-steroidal anti-inflammatory compound that demonstrates inhibition of Cox-1(ID₅₀=0.5 μM), Cox-2 (ID₅₀=14 μM), and γ-secretase. This compound has also been shown to be an inhibitor of Ras activation of Raf-1; it impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP. Sulindac Sulfide has been shown to inhibit growth and induce apoptosis in human prostate cancer cell cultures through a Cox-1 and Cox-2 independent mechanism. Sulindac Sulfide is an inhibitor of NFκB.

应用：An active metabolite of sulindac that inhibits for Cox

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