POV-PC,[(2R)-3-hexadecanoyloxy-2-(5-oxopentanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate,121324-31-0

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产品名称：POV-PC

产品别名：[(2R)-3-hexadecanoyloxy-2-(5-oxopentanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate

CAS号：121324-31-0

英文别名：[(2R)-3-hexadecanoyloxy-2-(5-oxopentanoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate

分子量：593.7

分子式：C₂₉H₅₆NO₉P

纯度：>98%

外观：见爱必信官网

保存方法：Store at -20° C

描述：POV-PC (1-(Palmitoyl)-2-(5-oxovaleroyl)-phosphatidylcholine), is one of the oxidized low-density lipoprotien (oxLDL) species derived from 2-arachidonoyl or eicosapentanoyl phospholipids. POV-PC confers CD36 scavenger receptor binding affinity more potently than any hydroperoxy PC species, and may be one of the more important structural determinants of oxLDL. Treatment of cultured endothelial cells with POV-PC stimulates monocyte binding, stimulates intracellular cAMP production, and strongly inhibits the LPS-induced binding of neutrophils. OxLDL particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position.

应用：An oxLDL with effects on cell signaling and binding

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