Polyglutamine Aggregation Inhibitor, PGL-137,2-二甲基氨基-6-苯并噻唑,943-04-4

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试剂描述：

产品名称：Polyglutamine Aggregation Inhibitor, PGL-137

产品别名：2-Dimethylamino-benzothiazol-6-ol

CAS号：943-04-4

英文别名：2-Dimethylamino-benzothiazol-6-ol

分子量：194.25

分子式：C₉H₁₀N₂OS

纯度：见爱必信官网

外观：见爱必信官网

保存方法：Store at 4° C

描述：Polyglutamine Aggregation Inhibitor, PGL-137 is a cell-permeable benzothiazole compound that binds to polyglutamine (polyQ)-containing β-sheet structures and acts as a polyQ-aggregation inhibitor of Huntington's disease (HD). Polyglutamine Aggregation Inhibitor, PGL-137 has been shown to be non-toxic and prevent HDQ51 (flag-tagged HD exon 1 protein with 51 glutamines)-aggregation in 293 Tet-Off (293 tetracycline-off) cells with an IC₅₀ of ~ 100 µM. Polyglutamine Aggregation Inhibitor, PGL-137 has also shown to be an inhibitor of Huntingtin.

应用：A cell-permeable benzothiazole compound

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