PDGFR Tyrosine Kinase Inhibitor VI, SU6668,PDGFR Tyrosine Kinase Inhibitor VI, SU6668,210644-62-5

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产品名称：PDGFR Tyrosine Kinase Inhibitor VI, SU6668

产品别名：PDGFR Tyrosine Kinase Inhibitor VI, SU6668

CAS号：210644-62-5

英文别名：PDGFR Tyrosine Kinase Inhibitor VI, SU6668

分子量：310.4

分子式：C₁₈H₁₈N₂O₃

纯度：>97%

外观：见爱必信官网

保存方法：Store at 4° C

描述：PDGFR Tyrosine Kinase Inhibitor VI, SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFRβ, VEGFR2 (Flk-1/KDR), FGFR1 activity in vitro (IC₅₀ = 0.01, 0.1, 3.9, and 3.8 µM, respectively) and PDGF/VEGF/bFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target ser/thr kinases Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK (IC₅₀ = 0.85, 0.047, 1.4, and 1.8 µM, respectively), as well as non-receptor TKs Lyn and Yes (IC₅₀ = 4.3 and 5.8 µM, respectively).

应用：A potent ATP-competitive inhibitor against tyrosine kinases

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