p38 MAP Kinase Inhibitor V,4-[3-(4-chlorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl]pyrimidine,271576-77-3

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产品名称：p38 MAP Kinase Inhibitor V

产品别名：4-[3-(4-chlorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl]pyrimidine

CAS号：271576-77-3

英文别名：4-[3-(4-chlorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl]pyrimidine

分子量：353.85

分子式：C₁₉H₂₀ClN₅

纯度：>90%

外观：见爱必信官网

保存方法：Store at -20° C

描述：p38 MAP Kinase Inhibitor V is a cell-permeable trisubstituted pyrazole compound that acts as a highly potent ATP-competitive inhibitor of casein kinase I δ (CK1δ) and p38α (IC₅₀ = 20 and 40 nM, respectively). Shown to affect p38β, PKA, JNK2, and JNK3 activity (IC₅₀ = 2.3, 10.5, 19.7, and 69.7 μM, respectively) only at much higher concentations and exhibit little effect against a panel of 44 other commonly studied kinases, including p38δ/γ, even at a conentraion of 10 μM or higher. An excellent tool for studying p38-mediated responses in cells in vitro.

应用：A cell-permeable highly potent ATP-competitive inhibitor of CK1 and p38

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