Niguldipine • HCl,(±)-尼古地平盐酸盐,113317-61-6

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产品名称：Niguldipine • HCl

产品别名：1,4-Dihydro-2,6-dimethyl-4-(3-n­itrophenyl)-3,5-pyridinedicarboxylic acid, 3-(4,4-diphenyl-1-piperidinyl)propyl methyl ester hydrochloride

CAS号：113317-61-6

英文别名：1,4-Dihydro-2,6-dimethyl-4-(3-n­itrophenyl)-3,5-pyridinedicarboxylic acid, 3-(4,4-diphenyl-1-piperidinyl)propyl methyl ester hydrochloride

分子量：646.18

分子式：C₃₆H₃₉N₃O₆•HCl

纯度：见爱必信官网

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保存方法：Store at room temperature

描述：Niguldipine HCl has been reported to be a highly selective α ₁-adrenoceptor antagonist and dihydropyridine calcium channel blocker. More specifically, Niguldipine HCl has been shown to irreversibly inhibit T-type calcium channel currents in certain types of central and peripheral neurons and in smooth muscle cells. This compound has also been noted to inhibit noradrenaline-stimulated inositol phosphate accumulation. Additional reports demonstrate that Niguldipine HCl can potently and specifically inhibit bTREK-1 (IC₅₀ = 5.07μM). Niguldipine HCl is an inhibitor of Mdr-1.

应用：A selective α 1-adrenoceptor antagonist and dihydropyridine calcium channel blocker

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