NF 449,NF 449,4,4',4'',4'''-[Carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino))]tetrakis-1,3-benzenedisulfonicacid,octasodiumsalt,389142-38-5

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试剂描述：

产品名称：NF 449

产品别名：4,4',4'',4'''-[Carbonylbis(imino-5,1,3-be nzenetriyl-bis(carbonylimino))]tetrakis-1,3-benzen edisulfonic acid octasodium salt

CAS号：389142-38-5

英文别名：4,4',4'',4'''-[Carbonylbis(imino-5,1,3-be nzenetriyl-bis(carbonylimino))]tetrakis-1,3-benzen edisulfonic acid octasodium salt

分子量：1505.09

分子式：C₄₁H₂₄N₆O₂₉S₈•8Na

纯度：≥95%

外观：light red

保存方法：Store at 4° C

描述：

NF 449 is a selective Gsα-subunit G-protein antagonist which reduces the association rate of guanosine 5'-[γ-thio]triphosphate ([35S]GTP[γS]) binding to G_{α s} -s (Gs&alpha-s) and inhibits the stimulation of adenylyl cyclase activity in S49 cyc- membranes. In addition, NF 449 interferes with binding between the Adenosine A1-R (A1-adenosine receptor) and its cognate G proteins (Gi/Go). Alternate studies suggest that NF449 inhibits a wide array of P2 receptors such as P2X3, P2Y1, and P2Y2, while showing the highest selectivity towards P2X1. Furthermore, NF449 can disrupt the coupling of β-AR (β-adrenergic receptors).

应用：A selective G-protein antagonist

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