Naphmethonium dibromide,Naphmethonium dibromide,505059-27-8

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产品名称：Naphmethonium dibromide

产品别名：Naphmethonium dibromide

CAS号：505059-27-8

英文别名：Naphmethonium dibromide

分子量：786.6

分子式：C₃₈H₅₀Br₂N₄O₄

纯度：见爱必信官网

外观：white to off-white

保存方法：Store at 4° C

描述：Naphmethonium dibromide is a very potent allosteric modulator of muscarinic receptors, selective for M2-receptors. Retards the dissociation of the antagonist N-methylscopolamine and exhibits positive cooperativity, i.e. shows higher affinity for occupied receptors compared to free receptors. Naphmethonium dibromide’s affinity for the free receptor is about 100-fold higher than with W84. pK_A =8.29, p(αK_A)=8.66, pEC_50,diss=8.36.

应用：A potent allosteric modulator of muscarinic receptors

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