Naltrindole Hydrochloride,纳曲吲哚盐酸盐,111469-81-9

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产品名称：Naltrindole Hydrochloride

产品别名：纳曲吲哚盐酸盐

CAS号：111469-81-9

英文别名：Naltrindole hydrochloride

分子量：451

分子式：C₂₆H₂₆N₂O₃ HCl

纯度：≥98%

外观：white solid

保存方法：Store at -20° C

描述：

Naltrindole Hydrochloride is the hydrochloride salt preparation of Naltrindole, which is an apoptotic agent and an inhibitor of cell growth. Naltrindole has been shown to be a cell permeable, highly potent and selective antagonist of DOR(δ opioids). Mechanistic studies show that Naltrindole treatement reduces phosphorylation of threonine 308 and Akt/PKB on serine 473 in cells. By reducing phosphorylation of Akt/PKB, downstream effectors glycogen synthase kinase-3β and transcription factors such as AFX and FKHR are also reduced.

应用：A δ opioid (DOR) receptor antagonist

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