免疫调节蛋白AIRE抗体,Anti-PGA1/AIRE抗体

产品名称：免疫调节蛋白AIRE抗体,Anti-PGA1/AIRE抗体 
中文名称：免疫调节蛋白AIRE抗体 
英文名称：Anti-PGA1/AIRE 
产品编号：byk-12453R 
产品规格：0.1ml/0.2ml
产品用途：科研实验
亚 型： IgG
贮 存： 贮存于-20℃
抗体的异质性。抗体的组成极为复杂，是由成千上万、多种多样的免疫球蛋白（Ig）分子所组成。这些Ig分子在形状、大小、结构以及氨基酸的组成和排列上，既相似，又有差别。由于有差别，它们的电泳活性就有很大的变化。
免疫调节蛋白AIRE抗体,Anti-PGA1/AIRE抗体 产品说明：
The autoimmune regulator gene, which is defective in the hereditary auto-immune disease APECED, encodes the transcriptional activator AIRE. AIRE is expressed in the medullary epithelial cells and monocyte-dendritic cells of the thymus, with lower expression in the spleen, fetal liver and lymph nodes. In adult tissue, AIRE expression in the thymus is confined to the medulla and the cortico-medullary junction, where it is modulated by thymocytes undergoing negative selection. At the cellular level, AIRE is located in microtubular structures of the cyto-skeleton and in discrete nuclear dots resembling ND10 nuclear bodies. AIRE is induced by developing early thymocytes and is associated with the correct establishment of a regular thymic environment. AIRE regulates thymic architecture via transcriptional control of downstream target genes. AIRE mutations in APECED patients may affect thymic T cell selection and the formation of self-tolerance.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 
免疫调节蛋白AIRE抗体,Anti-PGA1/AIRE抗体 相关产品：
Anti-Integrin a7（integrin alpha 7）  整合素α7抗体
Anti-Integrin β1/CD29(integrin beta 1)  整合素β1抗体
Anti-Integrin α5/CD49e/VLA-5（Integrin αV）  整合素α5抗体
Anti-Integrin α6/CD49f/VLA-6(Integrin alpha6/Laminin Receptor)  整合素α6抗体
Anti-Integrin β3/CD61(Integrin beta 3)  整合素β3抗体
Anti-JAK1(Tyrosine-protein kinase JAK1; Janus kinase 1)  蛋白质酪氨酸激酶JAK-1抗体
Anti-JAK2(Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2)  蛋白质酪氨酸激酶JAK-2抗体
Anti-phospho JAK2(phospho-Tyr1007+Tyr1008)  磷酸化蛋白酪氨酸激酶JAK-2抗体
Anti-JNK1/3 (c-Jun amino-terminal kinase 1/3)  c-Jun氨基末端激酶1/3抗体
Anti-Jab1(c-Jun activation domain-binding protein1)  Jun激活区域-连接蛋白1抗体
抗体结构:
抗体是具有4条多肽链的对称结构，其中2条较长、相对分子量较大的相同的重链(H链)；2条较短、相对分子量较小的相同的轻链(L链)。链间由二硫键和非共价键联结形成一个由4条多肽链构成的单体分子。轻链有κ和λ两种，重链有μ、δ、γ、ε和α五种。 整个抗体分子可分为恒定区和可变区两部分。在给定的物种中，不同抗体分子的恒定区都具有相同的或几乎相同的氨基酸序列。可变区位于"Y"的两臂末端。在可变区内有一小部分氨基酸残基变化特别强烈，这些氨基酸的残基组成和排列顺序更易发生变异区域称高变区。高变区位于分子表面，多由17个氨基酸残基构成，少则只有2 ～ 3个。高变区氨基酸序列决定了该抗体结合抗原抗原的特异性。一个抗体分子上的两个抗原结合部位是相同的，位于两臂末端称抗原结合片段(antigen-binding fragment, Fab)。"Y"的柄部称结晶片段(crystalline fragment,FC)，糖结合在FC 上。