二氢二醇脱氢酶1/2抗体,Anti-DD1/AKR1C1/DD2抗体

产品名称：二氢二醇脱氢酶1/2抗体,Anti-DD1/DD2抗体 
中文名称：二氢二醇脱氢酶1/2抗体 
英文名称：Anti-DD1/AKR1C1/DD2 
产品编号：byk-12454R 
产品规格：0.1ml/0.2ml
产品用途：科研实验
亚 型： IgG
贮 存： 贮存于-20℃
抗体的异质性。抗体的组成极为复杂，是由成千上万、多种多样的免疫球蛋白（Ig）分子所组成。这些Ig分子在形状、大小、结构以及氨基酸的组成和排列上，既相似，又有差别。由于有差别，它们的电泳活性就有很大的变化。
二氢二醇脱氢酶1/2抗体,Anti-DD1/DD2抗体 产品说明：
DD1 is also designated AKR1C1, DDH or DDH1, while DD2 also can be designated AKR1C2, dDD, BABP or DDH2. AKR1C3 and 3alpha-HSD are alternate designations for human DD3 (which is referred to as AKR1C18 in rodents), while DD4 also can be called AKR1C4, CD, CHDR or AKR1C6 (in rodents). DD1 and DD2 are 20alpha-HSDs, whereas DD3 and DD4 are the 3alpha-HSDs. The multiple human cytosolic dihydrodiol dehydrogenases are involved in the metabolism of xenobiotics, such as polycyclic aromatic hydrocarbons, pesticides and steroid hormones, and are responsible for the reduction of ketone-containing drugs by using NADH or NADPH as a cofactor. The 20alpha-HSD catalyzes the reaction of progesterone to the inactive form 20alpha-hydroxyprogesterone. The 3alpha-HSD is a cytosolic, monomeric, NADPH-dependent oxidoreductase that reduces 3-keto-5-dihydrosteroids to their tetrahydro products. DD1 and DD2 are ubiquitously expressed, whereas DD4 mRNA is restricted to the liver. DD3 is a unique enzyme that can specifically catalyze the dehydrogenation of trans-benzenedihydrodiol and trans-naphthalenedihydrodiol.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 
二氢二醇脱氢酶1/2抗体,Anti-DD1/DD2抗体 相关产品：
Anti-phospho-JNK1/2/3(pThr183/pTyr185)   抗磷酸化氨基末端激酶1/2/3抗体
Anti-JNK1/2/3  抗氨基末端激酶1/2/3抗体
Anti-p300/KAT3B  转录接头蛋白EP300抗体
Anti-KCNA5(Potassium voltage-gated channel subfamily A member 5)  钾电压阀门通道混合器相关亚家族成员5抗体
Anti-Ki-67  Ki-67 Antigen抗体
Anti-Ki-67（Antigen identified by monoclonal antibody Ki 67）  Ki67抗体
Anti-Ki-67（mo monoclonal）  小鼠Ki-67单克隆抗体
Anti-Kif14 protein   驱动蛋白家族Member14蛋白抗体
Anti-Kiss-1 (Metastasis-suppressor KiSS-1 precursor)  肿瘤转移YZ基因抗体
Anti-Klf4(Kruppel like factor 4)  肠道内富含的Kruppel样因子/上皮锌指蛋白4抗体
抗体结构:
抗体是具有4条多肽链的对称结构，其中2条较长、相对分子量较大的相同的重链(H链)；2条较短、相对分子量较小的相同的轻链(L链)。链间由二硫键和非共价键联结形成一个由4条多肽链构成的单体分子。轻链有κ和λ两种，重链有μ、δ、γ、ε和α五种。 整个抗体分子可分为恒定区和可变区两部分。在给定的物种中，不同抗体分子的恒定区都具有相同的或几乎相同的氨基酸序列。可变区位于"Y"的两臂末端。在可变区内有一小部分氨基酸残基变化特别强烈，这些氨基酸的残基组成和排列顺序更易发生变异区域称高变区。高变区位于分子表面，多由17个氨基酸残基构成，少则只有2 ～ 3个。高变区氨基酸序列决定了该抗体结合抗原抗原的特异性。一个抗体分子上的两个抗原结合部位是相同的，位于两臂末端称抗原结合片段(antigen-binding fragment, Fab)。"Y"的柄部称结晶片段(crystalline fragment,FC)，糖结合在FC 上。