Capmatinib(INCB28060),1029712-80-8

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产品名称：Capmatinib(INCB28060)

产品别名：INCB 28060; INCB-28060; INC280

英文别名：INCB 28060;INCB-28060;INC280

靶点：c-Met

CAS：1029712-80-8

纯度：>98%

外观：Powder

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.

描述：INCB28060 is a novel orally active inhibitor (IC50=0.13 nM) of c-MET kinase.

溶解性：DMSO2 mg/mL (4.84 mM)

体外研究：

INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases. INCB28060 inhibits human c-MET phosphorylation and c-MET-mediated signaling in cancer cells. INCB28060 inhibits c-MET-dependent cell proliferation and survival, and prevents anchorage-independent cancer cell growth and cell migration.

体内研究：INCB28060 shows strong antitumor activity in c-MET-dependent mouse tumor models, even oral treatment of 0.03 mg/kg INCB28060 causes approximately 50% inhibition of c-MET-phosphorylation. Dose-dependent inhibition of tumor growth is observed in tumor-bearing mice.

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