d-threo-PDMP,D-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL,109836-82-0

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产品名称：d-threo-PDMP

产品别名：D-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol • HCl

CAS号：109836-82-0

英文别名：D-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol • HCl

分子量：427.02

分子式：C₂₃H₃₈N₂O₃•HCl

纯度：≥98%

外观：见爱必信官网

保存方法：Store at -20° C

描述：d-threo-PDMP is an inhibitor of the enzyme UGCG (glycosylceramide synthase) which is the intial step in the glycosylation of ceramide. Studies show that d-threo-PDMP decreases cell surface glycosphingolipids via inhibiting glycosylation. It is believed that d-threo-PDMP can increase the number of ceramide in cells which in directly leads to apoptosis and stops cellular development. Axonal studies show that d-threo-PDMP reduces the total length of the axon plexus and the number of axonal branch points. Studies involving SH-SY5Y cells indicate that d-threo-PDMP can inhibit the outgrowth of neurite.

应用：A glucosylceramide synthetase inhibitor

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