CR8, (S)-Isomer,(2S)-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]butan-1-ol,1084893-56-0

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试剂描述：

产品名称：CR8, (S)-Isomer

产品别名：(2S)-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]butan-1-ol

CAS号：1084893-56-0

英文别名：(2S)-2-[[9-propan-2-yl-6-[(4-pyridin-2-ylphenyl)methylamino]purin-2-yl]amino]butan-1-ol

分子量：431.5

分子式：C₂₄H₂₉N₇O

纯度：≥97%

外观：见爱必信官网

保存方法：Store at -20° C

描述：CR8, (S)-Isomer is a cell-permeable (R)-DRF053 analog that acts as an ATP-binding pocket-targeting CDK/CK1 dual-specific inhibitor (IC₅₀ = 0.09, 0.072, 0.041, 0.11, 1.10, 0.18, and 0.40 μM against Cdc2(CDK1)/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK5/p35 (p25), CDK7/cyclin H, CDK9/cyclin T, and casein kinase I δ/ε (CK1δ/ε), respectively). (R)-CR8 inhibits CDK/CK1 more effectively than (R)-Roscovitine, while maintaining similar selectivity profile over other types of kinases (IC₅₀ = 3.6, 3.6, and 12.0 μM against Dyrk1A, ERK 2, and GSK-3α/β, respectively). Both (R)-CR8 and (S)-enantiomers are much more effective than (R)-Roscovitine in apoptosis induction in cell cultures.

应用：A cell-permeable (R)-DRF053 analog

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