TX-1123,2-[4-Hydroxy-3,5-bis(2-methyl-2-propanyl)benzylidene]-4-cyclopent ene-1,3-dione,157397-06-3

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试剂描述：

产品名称：TX-1123

产品别名：2-((3,5-di-tert-Butyl-4-hydroxyphenyl)-methylene)-4-cyclopentene-1,3-dione

CAS号：157397-06-3

英文别名：2-((3,5-di-tert-Butyl-4-hydroxyphenyl)-methylene)-4-cyclopentene-1,3-dione

分子量：312.4

分子式：C₂₀H₂₄O₃

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保存方法：Store at 4° C

描述：TX-1123 may be useful as a therapeutic agent for cancer treatment in animal models. A cell-permeable, reversible and substrate-competitive arylidene-cyclopentenedione derived tyrphostin that acts as a kinase inhibitor for proto-oncogene tyrosine-protein kinase Src (c-Src, IC₅₀ = 2.2 μM), eukaryotic elongation factor-2 kinase (eEF2-K, IC₅₀ = 3.2 μM), and protein kinase A (PKA, IC₅₀ = 9.6 μM). TX-1123 has been shown to inhibit EGFR-K and PKC, but only at much higher concentrations (IC₅₀ = 320 μM).

Additionally, TX-1123 has been reported to exhibit potent anti-tumor activity in HepG2(EC₅₀ = 3.66) and HCT116 (EC₅₀ = 39 μM) tumor cells, with greatly reduced mitochondrial- (≥1000-fold) and hepato-toxicity (≥50-fold) when compared with another tyrphostin, AG 17 .

应用：A tyrphostin that acts as a kinase inhibitor for c-Src, eEF2-K, and PKA

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