13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1-d4,

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产品名称：13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1-d4

产品别名：15-hydroxy Lubiprostone

CAS号：见爱必信官网

英文别名：15-hydroxy Lubiprostone

分子量：396.48

分子式：C₂₀H₃₀D₄F₂O₅

纯度：见爱必信官网

外观：见爱必信官网

保存方法：Store at -20° C

描述：PGE1 is produced by the metabolism of dihomo-γ-linolenic acid (DGLA) by the cyclooxygenase pathway. PGE1 inhibits platelet aggregation (IC₅₀ = 40 nM) and increases vasodilation.13,14-dihydro-16,16-difluoro PGE1 is a biologically active metabolite of PGE1, inhibiting platelet aggregation with comparable potency to the parent compound. The addition of two electron-withdrawing fluorine atoms, which should stabilize the molecule against hydrolytic cleavage, may be expected to delay degradation in vivo. 13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro PGE1-3,3’,4,4’-d4) contains four deuterium atoms at the 3, 3’, 4, and 4’ positions. It is intended for use as an internal standard for the quantification of 13,14-dihydro-15(R,S)-hydroxy-16,16-difluoro Prostaglandin E1 by GC- or LC-mass spectrometry (MS).

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