黑色素瘤硫酸软骨素蛋白多糖4抗体,Anti-NG2/CSPG4抗体

产品名称：黑色素瘤硫酸软骨素蛋白多糖4抗体,Anti-NG2抗体
中文名称：黑色素瘤硫酸软骨素蛋白多糖4抗体 
英文名称：Anti-NG2/CSPG4 
产品编号：byk-11192R 
产品规格：0.1ml/0.2ml
产品用途：科研实验
亚 型： IgG
贮 存： 贮存于-20℃
抗体的异质性。抗体的组成极为复杂，是由成千上万、多种多样的免疫球蛋白（Ig）分子所组成。这些Ig分子在形状、大小、结构以及氨基酸的组成和排列上，既相似，又有差别。由于有差别，它们的电泳活性就有很大的变化。
黑色素瘤硫酸软骨素蛋白多糖4抗体,Anti-NG2抗体 品说明：
NG2 (also known as melanoma-associated chondroitin sulfate proteoglycan 4, MCSP, MCSPG, MSK16 and MEL-CSPG) stabilizes cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. NG2 may facilitate primary melanoma progression by enhancing the activation of key signaling pathways important for tumor invasion and growth. Threonine 2256 phosphorylation of rat NG2 (Threonine 2252 phosphorylation of human NG2) leads to redistribution of NG2 on the surface of astrocytomas, polarization of the cell and a significant increase in cell motility. NG2 acts as a co-receptor for spreading and focal contact formation in association with Alpha 4 Beta1 integrin in malignant melanoma cells. NG2 is present on blood vessels throughout the rat embryo. Microvessels within the rat CNS express NG2 on endothelial cells, and outside the CNS, NG2 is present on smooth muscle cells. NG2 is a novel marker for epidermal stem cells that contributes to their patterned distribution by promoting stem cell clustering.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 
黑色素瘤硫酸软骨素蛋白多糖4抗体,Anti-NG2抗体 关产品：
Anti-M2-PK （ pyruvate Kinase M2）  丙酮酸激酶-M2抗体
Anti-M2-PK （pyruvate Kinase M2）  丙酮酸激酶-M2（小鼠来源抗体）
anti-Integrin alpha E2  整合素alpha E2 抗体
Anti-Integrin alpha L/CD11a（Integrin alpha-L precursor）  整合素αL抗体
Anti-MAC1/CR3A/CD11b/ITGAM(Integrin Alpha M)  整合素αM/巨噬细胞表面分子抗体
Anti-Integrin α X/CD11c(Integrin alpha-X)  整合素αX抗体
Anti-MARCO(Macrophage receptor MARCO)  巨噬细胞清道夫受体抗体
Anti-Mad1(mitosis arrest deficiency 1)  Mad1抗体
Anti-MAdCAM-1(Mucosal addressin cellular adhesion molecule-1)  粘膜血管定居因子抗体
Anti-FADD(Fas Associated Death Domain)  Fas相关死亡结构域蛋白抗体
抗体结构:
抗体是具有4条多肽链的对称结构，其中2条较长、相对分子量较大的相同的重链(H链)；2条较短、相对分子量较小的相同的轻链(L链)。链间由二硫键和非共价键联结形成一个由4条多肽链构成的单体分子。轻链有κ和λ两种，重链有μ、δ、γ、ε和α五种。 整个抗体分子可分为恒定区和可变区两部分。在给定的物种中，不同抗体分子的恒定区都具有相同的或几乎相同的氨基酸序列。可变区位于"Y"的两臂末端。在可变区内有一小部分氨基酸残基变化特别强烈，这些氨基酸的残基组成和排列顺序更易发生变异区域称高变区。高变区位于分子表面，多由17个氨基酸残基构成，少则只有2 ～ 3个。高变区氨基酸序列决定了该抗体结合抗原抗原的特异性。一个抗体分子上的两个抗原结合部位是相同的，位于两臂末端称抗原结合片段(antigen-binding fragment, Fab)。"Y"的柄部称结晶片段(crystalline fragment,FC)，糖结合在FC 上。