Hdm2 E3 Ligase Inhibitor,3,3,3-trifluoro-N-(4-sulfamoylphenyl)-2-(trifluoromethyl)propanamide,414905-09-2

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产品名称：Hdm2 E3 Ligase Inhibitor

产品别名：3,3,3-trifluoro-N-(4-sulfamoylphenyl)-2-(trifluoromethyl)propanamide

CAS号：414905-09-2

英文别名：3,3,3-trifluoro-N-(4-sulfamoylphenyl)-2-(trifluoromethyl)propanamide

分子量：350.2

分子式：C₁₀H₈F₆N₂O₃S

纯度：≥95%

外观：见爱必信官网

保存方法：Store at 4° C

描述：Hdm2 E3 Ligase Inhibitor is a cell-permeable and reversible inhibitor of Hdm2 E3 ligase that selectively blocks Hdm2 E3-mediated ubiquitination. Has been shown to inhibit ubiquitination of p53 in vitro (IC50 = 12.7 µM using Ub-Ubc as the donor substrate). Exhibits little effect towards other ubiquitin-using enzymes (IC50 > 100 µM for E1, Nedd-4, and SCF) or the auto-ubiquitination activity of Hdm2. The inhibition is non-competitive with respect to either the donor or acceptor substrate.

应用：A cell-permeable and reversible inhibitor of Hdm2 E3 ligase that selectively blocks Hdm2 E3-mediated ubiquitination

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