产品名称:CD163抗体,Anti-CD163/M130抗体
中文名称:CD163抗体
英文名称:Anti-CD163/M130
产品编号:byk-2527R
产品规格:0.1ml/0.2ml
产品用途:科研实验
亚 型: IgG
贮 存: 贮存于-20℃
抗体的异质性。抗体的组成极为复杂,是由成千上万、多种多样的免疫球蛋白(Ig)分子所组成。这些Ig分子在形状、大小、结构以及氨基酸的组成和排列上,既相似,又有差别。由于有差别,它们的电泳活性就有很大的变化。
CD163抗体,Anti-CD163/M130抗体 品说明:
CD163 is a 130 kDa membrane glycoprotein. It is a member of the scavenger receptor cysteine-rich superfamily and is a receptor for the hemoglobin-haptoglobin complex. CD163 is expressed exclusively on the cell surface of human monocytes and macrophages that evolve predominantly in the late phase of inflammation. CD163 is present on all CD14 positive monocytes, most CD64 positive monocytes, and shows higher expression on CD16 positive monocytes. CD163 is upregulated on mononuclear phagocytes by IL-10, IL-6 and dexamethasone. Lipopolysaccharide (LPS) and phorbol myristate acetate (PMA) both induce shedding of CD163 from the cell surface into plasma or cell supernatant.
保存条件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CD163抗体,Anti-CD163/M130抗体 关产品:
Anti-MASP1(Mannan binding lectin serine protease 1) 甘露聚糖结合凝集素丝氨酸肽酶1抗体
Anti-MASP2(mannan-binding lectin serine peptidase 2) 甘露聚糖结合凝集素丝氨酸肽酶2抗体
Anti-Matriptase 蛋白裂解酶(一种新的癌基因)抗体
Anti-MBP (Myelin Basic Protein) 髓鞘碱性蛋白抗体
Anti-HCMV PP65/HHV5 PP65(Cytomegalovirus PP65 ) 巨细胞病毒PP65/CMV低基质磷脂蛋白抗体
Anti-HCMV UL23/HHV5 UL23(Human Cytomegalovirus UL23 Gene) 人巨细胞病毒UL23抗体
Anti-HCMV UL49(Human Cytomegalovirus UL49 Gene) 人巨细胞病毒UL49抗体
Anti-MCP-1/CCL2 (monocyte chemotactic protein1)mouse, rat 单核细胞趋化蛋白1抗体(大、小鼠)
Anti-MCP-1/CCL2(Monocyte chemotactic protein 1)human 单核细胞趋化蛋白1抗体(人)
Anti-MCP-2/CCL8(Monocyte chemotactic protein 2)human 单核细胞趋化蛋白2抗体(人)
抗体结构:
抗体是具有4条多肽链的对称结构,其中2条较长、相对分子量较大的相同的重链(H链);2条较短、相对分子量较小的相同的轻链(L链)。链间由二硫键和非共价键联结形成一个由4条多肽链构成的单体分子。轻链有κ和λ两种,重链有μ、δ、γ、ε和α五种。 整个抗体分子可分为恒定区和可变区两部分。在给定的物种中,不同抗体分子的恒定区都具有相同的或几乎相同的氨基酸序列。可变区位于"Y"的两臂末端。在可变区内有一小部分氨基酸残基变化特别强烈,这些氨基酸的残基组成和排列顺序更易发生变异区域称高变区。高变区位于分子表面,多由17个氨基酸残基构成,少则只有2 ~ 3个。高变区氨基酸序列决定了该抗体结合抗原抗原的特异性。一个抗体分子上的两个抗原结合部位是相同的,位于两臂末端称抗原结合片段(antigen-binding fragment, Fab)。"Y"的柄部称结晶片段(crystalline fragment,FC),糖结合在FC 上。