L-trans-Pyrrolidine -2,4-dicarboxylic acid,L-反式-烷-2,4-二羧酸,64769-66-0

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产品名称：L-trans-Pyrrolidine -2,4-dicarboxylic acid

产品别名：L-反式-烷-2,4-二羧酸

CAS号：64769-66-0

英文别名：(2S,4R)-pyrrolidine-2,4-dicarboxylic acid

分子量：159.1

分子式：C₆H₉NO₄

纯度：98%

外观：见爱必信官网

保存方法：Store at room temperature

描述：L-trans-Pyrrolidine-2,4-dicarboxylic acid (L-trans-PDC) is a glutamate uptake blocker, serving as a "conformer mimic" of the glutamate molecule as recognized by EAAT (excitatory amino acid transporter) proteins. L-trans-PDC is demonstrated to increase extracellular glutamate concentration without affecting extracellular GABA levels. Blockade of glutamate uptake by L-trans-PDC has a correlated effect of inducing neuronal Ca²⁺ influx and massive NMDA receptor-mediated neuronal death. Specificity of L-trans-PDC for the EAAT protein over other glutamate-recognizing loci indicates a particular structural requirement for the EAAT binding site, satisfied by this structurally rigid pyrrolidine "conformer mimic" of glutamate. L-trans-Pyrrolidine-2,4-dicarboxylic acid is an inhibitor of EAAT1, EAAT2, EAAT3, EAAT4 and EAAT5.

应用：An inhibitor of the glutamate transporter EAAT

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