Ketorolac (tromethamine salt),酮咯酸氨丁三醇,74103-07-4

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产品名称：Ketorolac (tromethamine salt)

产品别名：酮咯酸氨丁三醇

CAS号：74103-07-4

英文别名：ketorolac tromethamine

分子量：376.4

分子式：C₁₅H₁₂NO₃ · C₄H₁₂NO₃

纯度：≥98%

外观：白色或类白色结晶性粉末

保存方法：Store at room temperature

描述：

Ketorolac (tromethamine salt) inhibits both isoforms of Cox in recombinant rat and human enzyme systems. Ketorolac inhibits rat Cox-1 (IC₅₀ of 0.27 μM), rat Cox-2 (IC₅₀ of 2.06 μM), human Cox-1 (IC₅₀ of 1.23 μM) and human Cox-2 (IC₅₀ of 3.50 μM). The (S) enantiomer of Ketorolac with rat Cox-1 (IC₅₀ of 0.10 μM) is approximately twice as potent as the racemate, whereas the (R)-enantiomer (IC₅₀ of > 100 μM) is virtually without activity. Ketorolac shows inhibition of eicosanoid formation in HEL cells (Cox-1, IC₅₀ of 0.025 μM) and LPS-stimulated Mono Mac 6 cells (Cox-2, IC₅₀ of 0.039 μM), but does not significantly inhibit NO accumulation in supernatants of LPS-stimulated RAW 264.7 cells up to 300 μM. Ketorolac significantly inhibits thymidine incorporation of human osteoblasts (hOBs) upon 24 hours treatment in a dose-dependent manner, and inhibits proliferation and arrests cell cycle at G0/G1 phase in hOBs.

应用：A non selective inhibitior of Cox-1 and Cox-2

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