JNJ 17203212,4-[3-(trifluoromethyl)pyridin-2-yl]-N-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamide,821768-06-3

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产品名称：JNJ 17203212

产品别名：4-[3-(TRIFLUOROMETHYL)-PYRIDIN-2-YL]-N-[5-(TRIFLUOROMETH YL)-PYRIDIN-2-YL]-1-PIPERAZINECARBOXAMIDE

CAS号：821768-06-3

英文别名：4-[3-(TRIFLUOROMETHYL)-PYRIDIN-2-YL]-N-[5-(TRIFLUOROMETH YL)-PYRIDIN-2-YL]-1-PIPERAZINECARBOXAMIDE

分子量：419.33

分子式：C₁₇H₁₅F₆N₅O

纯度：≥98%

外观：见爱必信官网

保存方法：Store at -20° C

描述：JNJ 17203212 is a high affinity transient receptor potential vanilloid 1 (TRPV1) receptor antagonist. TRPV1 is a Capsaicin receptor that behaves as a non-selective cation channel that is mainly found in the sensory neurons, and specifically detects painful stimuli, low pH and heat. The compound has been used to investigate TRPV1 in rodent and guinea pig sensory reflexes. Research indicates that JNJ 17203212 elevates the micturition reflex threshold for activation in rodent bladder studies, and in rats weakens colonic hypersensitivity.

应用：A high affinity TRPV1 receptor antagonist

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