IP3K Inhibitor,6-N-[(4-nitrophenyl)methyl]-2-N-[[3-(trifluoromethyl)phenyl]methyl]-7H-purine-2,6-diamine,519178-28-0

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产品名称：IP3K Inhibitor

产品别名：6-N-[(4-nitrophenyl)methyl]-2-N-[[3-(trifluoromethyl)phenyl]methyl]-7H-purine-2,6-diamine

CAS号：519178-28-0

英文别名：6-N-[(4-nitrophenyl)methyl]-2-N-[[3-(trifluoromethyl)phenyl]methyl]-7H-purine-2,6-diamine

分子量：443.39

分子式：C₂₀H₁₆F₃N₇O₂

纯度：≥95%

外观：见爱必信官网

保存方法：Store at 4° C

描述：IP3K Inhibitor is a cell-permeable 2,6-disubstituted purine compound that acts as a selective, ATP-competitive inhibitor of IP 3-K (IC₅₀ = 10.2 µM), the kinase that catalyzes the conversion of IP3 to IP4. Induces elevated cellular IP3 level and Ca²⁺-release in a dose-dependent manner (5 to 20 µM in HL60 cells). IP3K Inhibitor exhibits negligible inhibitory effect on Cdk1 (IC₅₀ >100 µM) and two other IP3 metabolizing enzymes, PLC and IP3 5-ppase, even at concentrations as high as 200 µM. IP3K Inhibitor is a useful alternative to the non-cell-permeable IP3 or IP3 analogs for studies involving intact cells.

应用：A selective, ATP-competitive inhibitor of IP 3-K

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