HELSS (Haloenol lactone suicide substrate, BEL, Bromoenol lactone),溴烯醇内酯,88070-98-8

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试剂描述：

产品名称：HELSS (Haloenol lactone suicide substrate, BEL, Bromoenol lactone)

产品别名：6-(Bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one

CAS号：88070-98-8

英文别名：6-(Bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one

分子量：317.18

分子式：C₁₆H₁₃BrO₂

纯度：98%

外观：见爱必信官网

保存方法：Store at -20° C

描述：Haloenol lactone (HELSS) is a potent and irreversible inhibitor that selectively targets and forms a covalent bond with myocardial group VI iPLA2 (calcium-independent phospholipase A2). Group VI iPLA2 (Calcium-independent phospholipase A2) is a mediator of arachidonic acid release from aortic smooth cells induced by vasopressin. Inhibition of arachidonic acid release was found to be saturable and specific due to HELSS's 1,000-fold selectivity for inhibition of calcium-independent versus calcium-dependent PLA2. HELSS has also been observed to inhibit cellular cytosolic magnesium-dependent PAP (phosphatidic acid phosphohydrolase) activity in intact P388D1 macrophages. It is noted that this compound is also a GST (glutathione S-transferases) inhibitor that could help prevent GST-mediated drug resistance. HELSS (Haloenol lactone suicide substrate, BEL, Bromoenol lactone) is an inhibitor of Chymotrypsin.

应用：An inhibitor of Ca-independent PLA2 and Mg-dependent PAP

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