FABP4 Inhibitor,2-(5-乙基-3,4-二苯基-吡唑-1-基)--3-基氧基]乙酸,300657-03-8

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产品名称：FABP4 Inhibitor

产品别名：2-((2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)acetic acid

CAS号：300657-03-8

英文别名：2-((2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)acetic acid

分子量：474.56

分子式：C₃₁H₂₆N₂O₃

纯度：97%

外观：见爱必信官网

保存方法：Store at 4° C

描述：FABP4 Inhibitor is a cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of A-FABP (adipocyte Fatty-Acid-Binding Protein) by targeting its fatty acid-binding pocket (K_i = < 2 nM in a competitive binding assay using 1,8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP's (K_i = 250 nM and 350 nM, respectively). FABP4 Inhibitor (A-FABP Inhibitor) has been shown to effectively block foam cell transformation and the cellular expression of inflammatory mediators in aP2-positive, but not aP2-negative, THP-1 macrophage in vitro, as well as improve the glucose metabolism and insulin sensitivity.

应用：A potent and selective inhibitor of adipocyte Fatty-Acid-Binding Protein

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