Demethylasterriquinone B1,5-(7-but-2-enyl-1H-indol-3-yl)-3-hydroxy-2-(2-propan-2-yl-1H-indol-3-yl)cyclohexa-2,5-diene-1,4-dione,78860-34-1

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产品名称：Demethylasterriquinone B1

产品别名：DMAQ-B1

CAS号：78860-34-1

英文别名：DMAQ-B1

分子量：506.59

分子式：C₃₂H₃₀N₂O₄

纯度：>95%

外观：见爱必信官网

保存方法：Store at -20° C

描述：Demethylasterriquinone B1 is a cell-permeable asymmetrical bis-indolylquinone insulin mimic with anti-diabetic activity in animal models. Selectively stimulates insulin receptor (IR) tyrosine kinase activity (EC₅₀ ~ 6 μM in CHO•IR cells), while showing little effect towards IGF-1R, EGFR, or PDGFR. Demethylasterriquinone B1 also acts as an agonist for Trk A, Trk B and Trk C (the neurotrophin receptors TrkA, B, and C) in both cortical neurons and dorsal root ganglion neurons (~ 20 μM). DMAQ-B1 and insulin show differential effects on cellular gene expression profiles and DMAQ-B1 is a more selective agonist than insulin for the IR-mediated activation of PI-3 kinase/Akt pathway. Demethylasterriquinone B1 is an activator of insulin R.

应用：A cell-permeable insulin mimic that does not affect IGF-1R, EGFR, or PDGFR

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