Cdk1/2 Inhibitor III,Cdk1/2 Inhibitor III,443798-55-8

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产品名称：Cdk1/2 Inhibitor III

产品别名：5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide

CAS号：443798-55-8

英文别名：5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide

分子量：425.44

分子式：C₁₅H₁₃F₂N₇O₂S₂

纯度：>95%

外观：见爱必信官网

保存方法：Store at 4° C

描述：Cdk1/2 Inhibitor III is a cell-permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC50 = 20 nM, 35 nM and 92 nM in HCT-116, HeLa, and A375 cells, respectively). Cdk1/2 Inhibitor III acts as a highly potent, ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC₅₀ = 600 pM and 500 pM, respectively) with selectivity over VEGF-R2 (IC₅₀ = 32 nM), GSK-3b (IC₅₀ = 140 nM), and a panel of eight other kinases (IC₅₀ ≥ 1 µM)

应用：A cell-permeable triazolo-diamine compound and ATP inhibitor

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