C75,反-4-羧基-5-辛基-3-甲基-丁内酯,191282-48-1

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试剂描述：

产品名称：C75

产品别名：4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid; (±)-C75

CAS号：191282-48-1

英文别名：4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid; (±)-C75

分子量：254.32

分子式：C₁₄H₂₂O₄

纯度：>98%

外观：见爱必信官网

保存方法：Store at -20° C

描述：C75 is an inhibitor of fatty acid synthase (FAS) reducing food intake and body weight in mice. Exhibits irreversible slow-binding biphasic inactivation of fatty acid synthase. Downregulates neuropeptide Y and Agouti-related protein expression. Has been proposed to activate CPT-1 activity in liver and adipose tissue, leading to increased fatty acid oxidation and energy production. Shows significant antitumor activity in human breast cancer cells. Suppresses DNA replication and induces apoptosis. FAS inhibition by C75 leads to a dramatic accumulation of the CDK inhibitor p27KIP1 from cytosol to cell nuclei.

应用：An inhibitor of FAS

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