公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! 试剂描述: 产品名称:CaM Kinase II (290-309), Calmodulin Antagonist 产品别名:Ca2+/calmodulin-dependent protein kinase II (290-309) CAS号:115044-69-4 英文别名:Ca2+/calmodulin-dependent protein kinase II (290-309) 分子量:2273.8 分子式:C103H185N31O24S 纯度:>97% 外观:见爱必信官网 保存方法:Store at -20° C 描述:CaM Kinase II (290-309), Calmodulin Antagonist is a potent, synthetic peptide inhibitor of CaMKII (Ca2+/calmodulin-dependent protein kinase II), which was derived from the cDNA sequence of the rat brain 50-kDa alpha subunit. The use of this inhibitory peptide elucidated the calmodulin binding and inhibitory domains, as well as the initial autophosphorylation site (Thr286) of CaMKII with an IC50 of 52 nM. This peptide product binds CaM (calmodulin) tightly and inhibits additional calmodulin-requiring enzymes, such as PDE (phosphodiesterase) and PP2B (calcineurin). Investigators used this product in STC-1 cells to study the regulation of L-type calcium channels and found the inhibitory peptide to block whole cell calcium currents. Additional research in T84 cells showed that this peptide reduced chloride current by approximately 70% without effect on the channels in parotid acinar cells. 应用:A potent CaMKII inhibitor 产品信息订购: 产品货号 | 产品名称 | 规格 | 价格 | 大包装及货期 | abs42014794 | CaM Kinase II (290-309), Calmodulin Antagonist | 500ug | 1768 | 立即咨询 | 产品更多信息请进入爱必信网站咨询 |