BIBB 515,(4-chlorophenyl)-[4-[[4-(4,5-dihydro-1,3-oxazol-2-yl)phenyl]methylidene]piperidin-1-yl]methanone,156635-05-1

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试剂描述：

产品名称：BIBB 515

产品别名：1-(4-chlorobenzoyl)-4-[[4-(4,​5-dihydro-2-oxazolyl)phenyl]methylene]-piperidine

CAS号：156635-05-1

英文别名：1-(4-chlorobenzoyl)-4-[[4-(4,​5-dihydro-2-oxazolyl)phenyl]methylene]-piperidine

分子量：380.9

分子式：C₂₂H₂₁ClN₂O₂

纯度：≥98%

外观：见爱必信官网

保存方法：Store at -20° C

描述：

BIBB 515 is a selective and potent inhibitor of 2,3-oxidosqualene cyclase (OSC) with an ED₅₀ value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. Total cholesterol was reduced by 19% in normalipemic hamsters at a dose of 55 mg/kg/day for 11 days and 25% in hyperlipemic hamsters at a dose of 148 mg/kg/day for 25 days. OSC is an important enzyme in the biosynthesis of animal, fungal and plant sterols. OSC catalyzes the conversion of (3S)-2,3-oxidosqualene to lanosterol, a precursor to cholesterol, in fungi and mammals.

应用：An OSC inhibitor

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