AG-1288,alpha-基-(3,4-二羟基-5-硝基)肉桂腈,116313-73-6

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试剂描述：

产品名称：AG-1288

产品别名：α-Cyano-(3,4-dihydroxy-5-nitro)cinnamonitrile

CAS号：116313-73-6

英文别名：α-Cyano-(3,4-dihydroxy-5-nitro)cinnamonitrile

分子量：231.2

分子式：C₁₀H₅N₃O₄

纯度：≥98%

外观：见爱必信官网

保存方法：Store at -20° C

描述：AG-1288 is a tyrosine kinase inhibitor. It has been shown in human amnion cells (IC₅₀ =21 mM) to block glucocorticoid-induced cytotoxicity, TNFα-induced cytotoxicity, and glucocorticoid-induced COX-2 activity. It has also been reported to protect mice against lipopolysaccharide-induced lethal toxicity. This effect correlates with its ability to block LPS-induced production of nitric oxide in macrophages, and tumor necrosis factor alpha.

应用：A tyrosine kinase inhibitor and cell protective agent

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