公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! YZ剂描述: 产品名称:Pregabalin 产品别名:普瑞巴林 英文别名:Lyrica;CI-1008;PD-144723 靶点:Others CAS:148553-50-8 纯度:>98% 外观:白色或类白色结晶粉末 保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述: Pregabalin (Lyrica) is a a 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Pregabalin selectively binds to alpha2delta (A2D) subunits of presynaptic voltage-dependent calcium channels (VDCCs) located in the central nervous system (CNS). Binding of pregabalin to VDCC A2D subunits prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; synaptic transmission is inhibited and neuronal excitability is diminished. Pregabalin does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation.? [1, 2] 溶解性:Water :30 mg/mL 体外研究: 体内研究: 产品信息订购: 产品货号 | 产品名称 | 规格 | 价格 | 大包装及货期 | abs816421 | Pregabalin | 10mg | 2640 | 立即咨询 | 产品更多信息请进入爱必信网站咨询 |