GSK-3 Inhibitor II,478482-75-6

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产品名称：GSK-3 Inhibitor II

产品别名：TIBPO; 2-Thio(3-iodobenzyl)-5-(1-pyridyl)-[1,3,4]-oxadiazole

英文别名：TIBPO;2-Thio(3-iodobenzyl)-5-(1-pyridyl)-[1;3;4]-oxadiazole

靶点：Others

CAS：478482-75-6

纯度：≥95%

外观：见爱必信官网

保存方法：Store at -20° C

描述：

GSK-3 Inhibitor II is a potent inhibitor of GSK-3β (glycogen synthase kinase-3β) (IC₅₀=390 nM). GSK-3 was first discovered to be involved in the control of glycogen metabolism, but has since been indicated in regulating a diverse range of cellular functions, such as neuronal cell survival and death. GSK-3β plays an important role in cardiomyopathies and has been shown to decrease MRP2 expression in neuronal growth factor (NGF)-induced PC-12 cells . Activation of GSK-3β plays a critical role in diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling.

溶解性：Soluble in DMSO (10 mg/ml), and ethanol.

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