公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! YZ剂描述: 产品名称:Nivolumab 产品别名:见爱必信官网 英文别名:Nivolumab 靶点:PD-1/PD-L1 CAS:946414-94-4 纯度:98% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder) 描述:Nivolumab is a programmed death receptor-1 (PD-1) blocking antibody to treat advanced (metastatic) non-small cell lung cancer. 溶解性: ( < 1 mg/ml refers to the product slightly soluble or insoluble ) 体外研究: Nivolumab binds to CHO cells expressing PD-1 with an EC50 of 1.66 nM, but does not bind to the parental CHO cell line. Nivolumab binds to PD-1 on activated T cells with an EC50 of 0.64 nM. Nivolumab also inhibits the interaction between PD-1 and its ligands, PD-L1 and PD-L2, with IC50 values of 2.52 and 2.59 nM, respectively. Nivolumab (1.5 ng/mL) can enhance T-cell reactivity in the presence of a T-cell receptor stimulus. 体内研究: Nivolumab (10 and 50 mg/kg, i.v.) is well tolerated in cynomolgus monkeys. Serum chemistry changes are limited to a reversible 28% decrease in T3 at week 13 in females treated with 50 mg/kg. T4 and TSH levels are unchanged. In males treated with 50 mg/kg, there are no changes in T3, T4, or TSH levels. Nivolumab exposure increases in an approximately dose-proportional manner between 10 and 50 mg/kg, with no substantial sex differences noted. 产品信息订购: 产品货号 | 产品名称 | 规格 | 价格 | 大包装及货期 | abs823067 | Nivolumab | 1mg | 3240 | 立即咨询 | 产品更多信息请进入爱必信网站咨询 |