Loganin,18524-94-2

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YZ剂描述：

产品名称：Loganin

产品别名：马钱苷

英文别名：Loganoside

靶点：AChE；BChE；BACE1

CAS：18524-94-2

纯度：≥98%

外观：White to off-white solid.

保存方法：Store at -20° C

描述：

溶解性：DMSO ：78 mg/mL (199.81 mM)

体外研究：

In SMN-deficient NSC34 cells, loganin increases cell viability, neurite length, and expressions of SMN, Gemin2, SMN-Gemin2 complex, p-Akt, p-GSK-3, p-CREB, BDNF and Bcl-2. Loganin attenuates H2O2-induced neuronal damage via suppressing MAPKs signals in SH-SY5Y cells. Loganin may directly promote the differentiation and inhibit the apoptosis of MC3T3-E1 cells and indirectly reduce bone resorption. Loganin could directly enhance the function of osteoblasts and elevate their survival rate, indirectly inhibit the function of osteoclastd and reduce the number of osteoclastd via RANKL from osteoblastd.

体内研究：Loganin provides benefits to SMA (pinal muscular atrophy) therapeutics via improving SMN (survival motor neuron) restoration, muscle strength and body weight. In type 2 diabetes mice, loganin not only lowers blood glucose but also attenuates hyperglycemia-induced inflammation, oxidative stress and apoptosis. Loganin improves spatial memory in streptozotocin-induced diabetic rats and exhibits antiamnesic activity in scopolamine-treated mice via acetylcholinesterase inhibition.

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