Ro 20-1724,29925-17-5

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产品名称：Ro 20-1724

产品别名：4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

英文别名：4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

靶点：PDE

CAS：29925-17-5

纯度：≥98%

外观：White solid

保存方法：Store at -20℃

描述：

Ro 20-1724 is a selective inhibitor of cGMP-insensitive PDE4 (type IV phosphodiesterase, PDE IV) found in immune cells which increase endothelial cAMP levels and stabilize the endothelial barrier. In addition, Ro 20-1724 inhibits PDE3 (type III phosphodiesterase, PDE III) enzymes that form complexes with PDE4 enzymes in cardiac tissue. Studies show that Ro 20-1724, like other PDE4 inhibitors, suppresses the release of cytokines and other inflammatory signals as well as inhibits the development of oxygen reactive species.

溶解性：Soluble in DMSO (200 mg/ml), and ethanol (40 mg/ml). Insoluble in water.

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