公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! YZ剂描述: 产品名称:Tebanicline hydrochloride 产品别名:见爱必信官网 英文别名:Tebanicline hydrochloride 靶点:nAChR CAS:203564-54-9 纯度:98% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder) 描述:Tebanicline hydrochloride (ABT594 hydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM. 溶解性: In Vitro: DMSO : ≥ 34 mg/mL (144.61 mM) * "≥" means soluble, but saturation unknown. Preparing Stock Solutions ConcentrationSolventMass | 1 mg | 5 mg | 10 mg |
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1 mM | 4.2533 mL | 21.2666 mL | 42.5333 mL | 5 mM | 0.8507 mL | 4.2533 mL | 8.5067 mL | 10 mM | 0.4253 mL | 2.1267 mL | 4.2533 mL |
*请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液,并请注意储备液的保存方式和期限。 体外研究: Tebanicline is a novel, potent cholinergic nAChR ligand with analgesic properties that shows preferential selectivity for neuronal nAChRs. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM. Functionally, tebanicline is an agonist. At the transfected human α4β2 neuronal nAChR in K177 cells, with increased 86Rb+ efflux as a measure of cation efflux, ABT-594 has an EC50 value of 140 nM with an intrinsic activitycompared with (−)-nicotine of 130%; at the nAChR subtype expressed in IMR-32 cells, an EC50 of 340 nM; at the F11 dorsal root ganglion cell line, an EC50 of 1220 nM; and via direct measurement of ion currents, an EC50 value of 56,000 nM at the human α7 homo-oligimeric nAChR produced in oocytes 体内研究:Tebanicline is a novel, potent cholinergic nAChR ligand with analgesic properties that shows preferential selectivity for neuronal nAChRs. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM. Functionally, tebanicline is an agonist. At the transfected human α4β2 neuronal nAChR in K177 cells, with increased 86Rb+ efflux as a measure of cation efflux, ABT-594 has an EC50 value of 140 nM with an intrinsic activitycompared with (−)-nicotine of 130%; at the nAChR subtype expressed in IMR-32 cells, an EC50 of 340 nM; at the F11 dorsal root ganglion cell line, an EC50 of 1220 nM; and via direct measurement of ion currents, an EC50 value of 56,000 nM at the human α7 homo-oligimeric nAChR produced in oocytes 产品信息订购: 产品货号 | 产品名称 | 规格 | 价格 | 大包装及货期 | abs821466 | Tebanicline hydrochloride | 1mg | 330 | 立即咨询 | 产品更多信息请进入爱必信网站咨询 |