Tiagabine hydrochloride,145821-59-6

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产品名称：Tiagabine hydrochloride

产品别名：盐酸噻加宾

英文别名：NO050328 hydrochloride;NO328 hydrochloride;TGB hydrochloride

靶点：GABA uptake

CAS：145821-59-6

纯度：98%

外观：白色或类白色结晶性粉末

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Tiagabine Hydrochloride is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective <b>gamma-aminobutyric acid (GABA) reuptake</b> inhibitor.

溶解性：DMSO ：41.2 mg/mL (100 mM)
water : 20.6 mg/mL (50 mM)

体外研究：

Tiagabine is a potent inhibitor of GABA uptake into neurons and glial cells. It is involved in modulating GABA levels, especially in areas such as the hippocampus and thalamus. Tiagabine not only affected the decay kinetics of the IPSCs, it also reduced the frequency of occurrence of both spontaneous and miniature IPSCs.

体内研究：Tiagabine offers a significant neuroprotection in global ischemia in gerbils when given 30 min before ischemia but not when given 3 h after ischemia.

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