Vecuronium bromide,50700-72-6

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产品名称：Vecuronium bromide

产品别名：维库溴铵

英文别名：ORG NC 45

靶点：AChR

CAS：50700-72-6

纯度：＞98%

外观：白色或类白色粉末

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Vecuronium (bromide) is a muscle relaxant in the category of non-depolarizing blocking agents.

溶解性：DMSO : 93 mg/mL (145.8 mM)
Ethanol : 93 mg/mL (145.8 mM)
Water : 4 mg/mL (6.27 mM)

体外研究：

Vecuronium inhibits both forms of the muscle-type acetylcholine receptor with IC50 of 1-2 mM. Vecuronium combined with methylprednisolone shows additive effects on both receptor forms, which is best described by a two-site model, with each site independent. Vecuronium interferes with nicotinic processes in the carotid body and inhibits the chemoreceptor neural response to hypoxia. Vecuronium significantly attenuates the increase in CSNA (DeltaCSNA) in response to hypoxia in the carotid body.

体内研究：Vecuronium (a monoquaternary ammonium compound) has a higher biliary clearance than pancuronium (a bisquaternary ammonium compound) in the rats.

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