Fluoxetine hydrochloride,56296-78-7

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YZ剂描述：

产品名称：Fluoxetine hydrochloride

产品别名：盐酸氟西汀

英文别名：LY-110140

靶点：5-HT

CAS：56296-78-7

纯度：0.99

外观：白色或类白色结晶性粉末

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Fluoxetine HCl is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.

溶解性：DMSO : 34.6 mg/mL (100 mM)
water : 3.5 mg/mL (10 mM)

体外研究：

Fluoxetine blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell. Fluoxetine increases the number of newborn cells in the dentate gyrus of the hippocampus of adult rat. Fluoxetine also increases the number of proliferating cells in the prelimbic cortex. Fluoxetine accelerates the maturation of immature neurons. Fluoxetine enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus. Fluoxetine, but not citalopram, fluvoxamine, paroxetine and sertraline, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Fluoxetine produces robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration.

体内研究：Fluoxetine treatment also reverses the deficit in escape latency observed in animals exposed to inescapable shock in adult male Sprague–Dawley rats. Fluoxetine combined with Olanzapine produces robust, sustained increases of extracellular levels of dopamine ((ex)) and norepinephrine ((ex)) up to 361% and 272% of the baseline, respectively, which are significantly greater than either drug alone.

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