Atenolol,29122-68-7

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

YZ剂描述：

产品名称：Atenolol

产品别名：阿替洛尔

英文别名：(RS)-Atenolol

靶点：β1 receptor；β2 receptor

CAS：29122-68-7

纯度：98%

外观：白色粉末

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Atenolol is a selective β1 receptor antagonist.

溶解性：DMSO ：53 mg/mL (198.99 mM)
Ethanol：53 mg/mL (198.99 mM)
Water ：35 mg/mL (131.41 mM)

体外研究：

体内研究：In clinical pharmacokinetics studies, atenolol is a hydrophilic betareceptor blocking drug, which is predominantly eliminated via the kidneys, only about 5% of the atenolol is metabolised by the liver. After oral administration atenolol is incompletely absorbed from the intestine, so about 50% of the beta blocker are finally biovailable. In plasma only 3% of atenolol are protein-bound. After oral administration elimination half life of atenolol is calculated from 6 to 9 h. There exists a linear relationship between the atenolol plasma levels and the degree of beta blocking effect measured by inhibition of the exercise-induced tachycardia while no correlation is found between plasma levels of atenolol and blood pressure lowering activity of the drug.

产品信息订购：

产品更多信息请进入爱必信网站咨询