4-Hydroxybenzyl alcohol,623-05-2

体外研究：

4-hydroxybenzyl alcohol has been shown to suppress inflammation, which is most probably due to its capability of reducing cyclooxygenase activity. HBA acts as a typical pleiotropic agent, which targets multiple mechanisms of angiogenesis, including production of angiogenic growth factors and MMPs, endothelial cell proliferation and migration as well as vascular sprouting and network formation.

体内研究：4-hydroxybenzyl alcohol inhibits the vascularization of newly developing tumors and that this is associated with a reduced growth rate of the malignant tissue. It ameliorates cerebral ischaemic injury due to the inhibition of apoptotic pathways and the up-regulation of protein disulphide isomerase without inducing any toxic effects at doses up to 200 mg/kg. It exerts an anxiolytic-like action via the activation of the 5-hydroxytryptaminergic nervous system.

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