ICI 118,551 hydrochloride,72795-01-8

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产品名称：ICI 118,551 hydrochloride

产品别名：ICI 118551 hydrochloride

英文别名：ICI 118551 hydrochloride

靶点：β2 receptor；β1 receptor；β3 receptor

CAS：72795-01-8

纯度：≥98%

外观：white powder

保存方法：Store at -20° C

描述：

ICI 118,551 (hydrochloride) is a highly selective β2 adrenergic receptor antagonist, with Kis of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively. 

溶解性：H2O : 5 mg/mL (15.93 mM; Need ultrasonic and warming)

体外研究：

ICI 118551 inhibits cAMP accumulation with IC50 of 1.7 μM in IMCD cells. ICI 118551 (10 μM) induces a prominent vasorelaxation of norepinephrine (NE)-precontracted PA but not AO. In failing human heart, ICI 118551 has significant effects on beat duration, with time-to-peak contraction and time-to-90% relaxation reduced compared with basal contraction. Negative Inotropic Effect of ICI 118551 Is Not cAMP-Related. Overexpression of β2AR in rabbit myocytes enhances negative inotropic effects of ICI 118551.

体内研究：ICI 118551 (0.2 mg/kg) injected into the jugular vein of the mice, reduces systolic pressure in the pulmonary circuit but not systemic arterial pressure.

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