Substance P,33507-63-0

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YZ剂描述：

产品名称：Substance P

产品别名：多肽物质P

英文别名：Neurokinin P

靶点：Neurokinin Receptor

CAS：33507-63-0

纯度：98%

外观：Lyophilized solid

保存方法：Store at -20° C

描述：

Substance P 是一种神经肽，作为神经递质和神经调节剂。Substance P 的内源性受体是神经激肽1受体 (neurokinin 1 receptor，NK1R）

溶解性：Soluble in water (1 mg/ml), DMSO, and 5% Acetic Acid.

体外研究：

The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells.

体内研究：

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