公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! YZ剂描述: 产品名称:CGS 21680 Hydrochloride 产品别名:[3H]-CGS 21680A 英文别名:CGS 21680A;CGS 21680 HCl 靶点:Adenosine A2 receptor CAS:124431-80-7 纯度:>98% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述: CGS 21680 Hydrochloride is an <b>adenosine A2 receptor</b> agonist with <b>IC50</b> of 22 nM, exhibits 140-fold over A1 receptor. 溶解性:DMSO :107mg/mL(199.63mM) 体外研究: CGS 21680 HCl is an adenosine A2 receptor agonist with IC50 of 22 nM, exhibits 140-fold over A1 receptor. In an isolated perfused working rat heart model, CGS 21680C effectively increases coronary flow with an ED25 value of 1.8 nM. CGS 21680 binds adenosine A2 receptor with high affinity (Kd = 15.5 nM) and limited capacity (apparent Bmax = 375 fmol/mg of protein) to a single dass of recognition sites. In hippocampal slices, CGS 21680 apis weak agonist on pre- and postsynaptic measures of electrophysiologicaJ activity (putative Al receptor mediated events) and is ineffective at stimulating the formation of cAMP (a putative A2 mediated response). In striatal slices, CGS 21680 potently stimulates the formation of cAMP with an EC50 of 110 nM but is ineffective at inhibiting electrically stimulated dopamine release. CGS 21680A is the hydrochloride salt, while CGS 21680C is the sodium salt of CGS 21680. 体内研究:CGS 21680A is active p.o. in the spontaneously hypertensive rat at a dose of 10 mg/kg with efficacy for up to 24 hr. CGS 21680A caused a transient (60 min) increase in heart rate. CGS 21680 is a potent depressant of the spontaneous, acetylcholine and glutamate evoked firing of rat cerebral cortical neurons. 产品信息订购: 产品货号 | 产品名称 | 规格 | 价格 | 大包装及货期 | abs815960 | CGS 21680 Hydrochloride | 5mg | 865 | 立即咨询 | 产品更多信息请进入爱必信网站咨询 |