Olopatadine hydrochloride,140462-76-6

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YZ剂描述：

产品名称：Olopatadine hydrochloride

产品别名：盐酸奥洛他定

英文别名：ALO4943A;KW4679

靶点：Histamine Receptor

CAS：140462-76-6

纯度：>98%

外观：白色至类白色粉末

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Olopatadine hydrochloride (Opatanol) is a histamine blocker and mast cell stabilizer with an IC50 of 559 uM for the release of histamine. Evaluation of the interaction of olopatadine with histamine receptors revealed a relatively high affinity for the H1 receptor (Ki = 31.6 nM, pKi = 7.5 ?0.1) but lower affinities for H2 receptors (Ki = 100 uM, pKi = 4.0 ?0.19) and H3 receptors (Ki = 79.4 uM, pKi = 4.1 ?0.16,). The H1 selectivity of olopatadine was superior to that of other ocularly used anti-histamines studied, such as ketotifen, levocabastine, antazoline and pheniramine.

溶解性：DMSO ：37.4 mg/mL (100 mM)
Water ：28 mg/mL (75 mM)

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