Batimastat,130370-60-4

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YZ剂描述：

产品名称：Batimastat

产品别名：巴马司他

英文别名：BB-94;BB 94;BB94

靶点：MMP-1 ，MMP-2 ，MMP-9 ，MMP-7 ，MMP-3

CAS：130370-60-4

纯度：＞98%

外观：white powder

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Batimastat (BB-94)是一种有效的，广谱matrix metalloprotease (MMP)（基质金属蛋白酶）YZ剂，作用于MMP-1， MMP-2， MMP-9， MMP-7和MMP-3，IC50分别为3 nM， 4 nM， 4 nM， 6 nM和20 nM。

溶解性：DMSO : 47.8 mg/mL (100 mM)

体外研究：

Batimastat (BB-94) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 with IC50 of 3 nM, 4 nM, 4 nM, 6 nM and 20 nM, respectively. Batimastat exhibits an unexpected binding geometry, with the thiophene ring deeply inserted into the primary specificity site.

体内研究：Batimastat can inhibit metastatic spread and growth of B16-BL6 murine melanoma. In an orthotopic colon tumor model in mice, timastat treatment results in inhibition of primary tumor growth (by 50%), local/regional spread(from 67% to 35%), and distant metastasis(from 30% to 10%).Batimastat reduces in vivo growth of experimental hemangiomas, most probably by blocking endothelial cell recruitment by the transformed cells or by interfering with cell organization in vascular structures.

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