JZL-195,1210004-12-8

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产品名称：JZL-195

产品别名：JZL-195；JZL 195；JZL195

英文别名：JZL-195;JZL 195;JZL195

靶点：FAAH

CAS：1210004-12-8

纯度：>98%

外观：白色至淡黄色粉末

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50 = 2 and 4 nM, respectively).

溶解性：DMSO : ≥ 42 mg/mL (96.89 mM)

体外研究：

JZL195 produces near-complete blockade of FP-Rh labeling of both mouse brain FAAH and MAGL at concentrations as low as 100 nM (IC₅₀ values of 13 and 19 nM, respectively).
JZL195 inhibits rat and human FAAH and MAGL enzymes with IC₅₀ values in the range of ≈10-100 nM based on competitive ABPP assays.

体内研究：

Systemic administration of JZL195 reduces horizontal and vertical motor activity dose-dependently, and increases time spent in immobility. JZL195 produces a pronounced 2-AG elevation at all doses, and increases brain AEA and OEA levels due to its inhibitory activity at FAAH.

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